Navigating the intricate landscape of dental implantology amidst systemic diseases demands a nuanced understanding and approach. The comprehensive review by Donos and Calciolari delves deep into how systemic health conditions and their associated medications influence the success of dental implants. It highlights the paramount importance of meticulous patient selection, informed by a thorough medical history and the complexity of the surgical site. This narrative is not just about the challenges; it offers a beacon of guidance with practical suggestions for clinicians, aiming to mitigate risks and optimise outcomes. It also casts a spotlight on the need for further research to refine our understanding of these interactions. This exploration serves as a crucial resource for dental professionals, ensuring they are well-equipped to provide care that combines the dual goals of patient safety and implant success.